Sepsis Screening
qSOFA → SOFA Score → Bundle Initiation
This pathway implements the Sepsis-3 consensus definition: life-threatening organ dysfunction caused by a dysregulated host response to infection (SOFA ≥ 2). It begins with the bedside qSOFA screen for rapid identification, then guides SOFA scoring for confirmed organ dysfunction, and concludes with Surviving Sepsis Campaign Hour-1 Bundle recommendations. Early recognition and bundle initiation within 1 hour of sepsis identification reduces in-hospital mortality.
Pathway Steps
Suspected Infection
Required prerequisite for sepsis evaluation
qSOFA Screen
Quick Sequential Organ Failure Assessment — 3 bedside criteria
SOFA Score
Score each organ system 0–4: • Respiration: 0=PaO₂/FiO₂≥400, 1=<400, 2=<300, 3=<200+vent, 4=<100+vent • Coagulation: 0=Plts≥150k, 1=<150k, 2=<100k, 3=<50k, 4=<20k • Liver: 0=Bili<1.2, 1=1.2–1.9, 2=2–5.9, 3=6–11.9, 4=≥12 mg/dL • Cardiovascular: 0=MAP≥70, 1=MAP<70, 2=Dopa≤5, 3=Dopa>5 or Epi/NE≤0.1, 4=Dopa>15 or Epi/NE>0.1 mcg/kg/min • CNS: 0=GCS 15, 1=13–14, 2=10–12, 3=6–9, 4=<6 • Renal: 0=Cr<1.2, 1=1.2–1.9, 2=2–3.4, 3=3.5–4.9, 4=≥5 mg/dL
Clinical Disclaimer
This pathway is for educational purposes and clinical decision support only. Sepsis is a time-critical emergency — do not delay treatment for scoring. All clinical decisions require the judgment of a licensed healthcare professional familiar with the patient's full clinical context.