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Infectious Disease
Estimate vancomycin AUC/MIC from dose, interval, trough level, and weight. Target AUC/MIC 400–600 for MRSA per 2020 ASHP/IDSA/SIDP guidelines. Adjust dose for renal impairment.
Formula
Simplified first-order PK: Vd = 0.7 L/kg, ke = ln(Cpeak/Ctrough)/interval, CL = ke × Vd, AUC₂₄ = Daily dose / CL.
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Clinical
Calculate creatinine clearance (CrCl) using the Cockcroft-Gault equation. Used for renal drug dosing adjustments based on kidney function.
Formula
CrCl = [(140 − age) × weight] / (72 × Scr) × 0.85 if female
Inputs