Printed on 7/20/2026
For informational purposes only. This is not medical advice.
HADS is a 14-item questionnaire with two 7-item subscales: anxiety (HADS-A) and depression (HADS-D). It is commonly used in outpatient and medically ill populations because it limits heavy somatic weighting.
Formula: HADS-A = sum of 7 anxiety items (0-21); HADS-D = sum of 7 depression items (0-21); total = 0-42.
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The patient independently completes 14 questions about how they have felt during the past week. Items alternate between anxiety (A1-A7, odd-numbered) and depression (D1-D7, even-numbered) questions, each rated on a 4-point scale (0-3) with subscale-specific response anchors.
Sum the 7 anxiety items (HADS-A, range 0-21) and 7 depression items (HADS-D, range 0-21) as separate subscale scores. The total score (0-42) reflects overall emotional distress but clinical interpretation uses the subscales.
For each subscale: 0-7 = normal/no case; 8-10 = borderline/possible case; 11-21 = probable case. A score ≥8 on either subscale warrants clinical follow-up for the corresponding disorder (anxiety or depression). Probable case (≥11) requires formal diagnostic evaluation.
Hospital Nurses & Physicians
HADS was specifically designed for medically ill patients to detect psychological comorbidity without somatic item confounding. It is the most widely used anxiety and depression screening tool in hospital inpatient and outpatient settings globally.
Oncology Nurses & Palliative Care Teams
HADS is extensively validated in cancer patients, where somatic symptoms (fatigue, weight loss, appetite changes) overlap substantially with depression and anxiety symptoms. Its somatic-free design makes it particularly suited for oncology psychological screening.
Cardiologists & Chronic Disease Specialists
Depression after myocardial infarction affects 15-30% of patients and independently worsens outcomes. HADS screens for depression and anxiety in post-MI, heart failure, COPD, and diabetes patients without somatic symptom contamination.
General Medicine Physicians
In general medical outpatient settings, HADS provides a validated dual-domain screen for anxiety and depression as psychological comorbidities of physical illness, identifying patients who need mental health referral alongside medical management.
Surgeons & Anesthesiologists
Preoperative anxiety and depression predict worse surgical outcomes, longer hospital stays, and higher opioid consumption. HADS administered preoperatively identifies patients who may benefit from psychological support to optimize surgical outcomes.
HADS was designed by Zigmond and Snaith (1983) specifically to avoid somatic symptoms (fatigue, sleep disturbance, appetite, weight change) that overlap with medical illness, making it more specific than PHQ-9 or HAM-A for detecting psychological disorders in physically ill patients.
Clinical interpretation of HADS uses HADS-A and HADS-D as separate subscales (each 0-21), not the combined total (0-42). While total score reflects overall distress, treatment decisions are made based on which subscale is elevated — anxiety treatment vs depression treatment.
While HADS is the gold standard in hospital/medical settings, PHQ-9 and GAD-7 have more robust primary care validation, briefer administration, and are more familiar to primary care teams. Use HADS when somatic item contamination is the specific concern (cancer, cardiac, pulmonary disease patients).
The HADS depression subscale was deliberately designed around anhedonia (loss of interest and pleasure) — a core DSM feature of major depression — rather than somatic symptoms. This makes HADS-D specifically sensitive to the psychological core of depression.
Anxiety and depression in hospitalized patients are independently associated with longer lengths of stay, higher readmission rates, worse treatment adherence, and increased mortality in chronic diseases. Systematic HADS screening can identify high-risk patients for early psychological intervention.
The minimum clinically important difference for HADS subscales is approximately 1.5-2 points, meaning changes of this magnitude represent genuine clinical improvement beyond measurement noise. Use this threshold when monitoring HADS serially during treatment.
HADS-D and PHQ-9 correlate at r=0.74-0.87; HADS-A and GAD-7 correlate at r=0.72-0.85 in validation studies. This means the tools are largely interchangeable for screening purposes — use whichever is most institutionally standard, as training and familiarity improve consistent implementation.
A score of 8-10 on HADS-A or HADS-D represents a 'borderline/possible case' requiring clinical follow-up interview to determine if criteria for an anxiety or depressive disorder are met. Score ≥11 on either subscale represents a 'probable case' requiring formal diagnostic evaluation and likely treatment.
HADS developed by Zigmond & Snaith (Acta Psychiatr Scand 1983) specifically for non-psychiatric medical outpatients. Meta-analysis of 747 studies by Bjelland et al. (J Psychosom Res 2002): HADS-A and HADS-D each have AUC ~0.80 at threshold ≥8. Widely validated in oncology, cardiology, and chronic disease populations. HADS excludes somatic items by design to avoid confounding in physically ill patients. WHO-5 and PHQ-9 are alternatives in primary care settings where HADS may be over-inclusive.
Higher HADS-A/HADS-D subscale scores indicate stronger anxiety/depression symptom burden and support targeted follow-up assessment.
Use when brief dual-domain anxiety/depression screening is needed, especially in medical settings where somatic symptoms may confound other scales.
HADS is a screening tool and may not capture full diagnostic complexity, comorbidity, or disorder-specific criteria without comprehensive interview.
Disclaimer: This tool is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about your health.
April 21, 2026 · trust-baseline
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