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Printed on 6/22/2026
For informational purposes only. This is not medical advice.
The PREVENT (Predicting Risk of cardiovascular disease EVENTs) Risk Calculator implements the American Heart Association's 2024 risk equations, the contemporary successor to the 2013 Pooled Cohort Equations (PCE). PREVENT estimates 10-year risk of total cardiovascular disease (atherosclerotic CVD plus heart failure), ASCVD alone, and heart failure alone. Unlike the PCE, it is validated from age 30 (not 40), uses sex-specific equations instead of race-based coefficients, and incorporates kidney function (eGFR) and body mass index — recognizing the cardiovascular-kidney-metabolic (CKM) syndrome. Enter age, sex, total and HDL cholesterol, systolic blood pressure, eGFR, BMI, and treatment/diabetes/smoking status to get all three risk estimates. Compare with the older [ASCVD Risk Calculator](/tools/ascvd-risk) and [Framingham Risk Score](/tools/framingham-risk).
Formula: AHA PREVENT base-model equations (Khan et al., Circulation 2024) — sex-specific logistic models on centered, spline-transformed predictors (age, non-HDL-C, HDL-C, SBP, diabetes, smoking, BMI, eGFR, antihypertensive and statin use) for 10-year total CVD, ASCVD, and heart failure.
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Provide age (30–79), sex, total and HDL cholesterol, systolic blood pressure, eGFR, BMI, and whether the patient is on blood-pressure or statin therapy, has diabetes, or smokes. eGFR and BMI are new to PREVENT and reflect the cardiovascular-kidney-metabolic link.
The calculator uses the published 2024 base-model coefficients (sex-specific, no race term) to compute 10-year probabilities for three outcomes: total CVD, ASCVD, and heart failure.
ASCVD risk maps to familiar statin-decision thresholds (<5%, 5–7.5%, 7.5–20%, ≥20%). Total CVD adds heart failure, and the separate heart-failure estimate flags patients who may benefit from earlier metabolic and blood-pressure intervention.
Primary care physicians, cardiologists
Estimate 10-year cardiovascular risk to guide statin and blood-pressure treatment discussions using the AHA's current recommended model.
Family medicine, internal medicine
PREVENT is validated from age 30, allowing earlier risk conversations than the Pooled Cohort Equations (which start at 40).
Cardiologists, primary care
PREVENT is the first major risk model to output a dedicated 10-year heart-failure estimate, useful for patients with obesity, diabetes, or kidney disease.
Nephrologists, endocrinologists, cardiologists
By including eGFR and BMI, PREVENT operationalizes the cardiovascular-kidney-metabolic (CKM) syndrome framework in routine risk assessment.
Across most populations PREVENT yields lower 10-year ASCVD estimates than the 2013 Pooled Cohort Equations, which tended to overestimate. Do not directly substitute old thresholds without considering this shift; current statin thresholds were derived using the PCE.
Like the PCE, PREVENT estimates risk of a first event. Patients with established ASCVD already qualify for secondary-prevention statin therapy regardless of the score.
PREVENT explicitly models kidney function. If you do not have a recent eGFR, estimate it with the [eGFR Calculator](/tools/egfr-calculator) before running PREVENT.
In the base model, BMI coefficients are zero for ASCVD and total CVD's atherosclerotic component but contribute to heart-failure risk. Accurate height and weight matter most for the HF output — check [BMI](/tools/bmi-calculator).
PREVENT removed race as an input, using sex-specific equations instead. This was a deliberate move away from race-based medicine; clinical context and social determinants should still inform decisions.
This calculator implements the base-model coefficients of the American Heart Association's PREVENT equations (Khan SS et al., 'Development and Validation of the American Heart Association's Predicting Risk of cardiovascular disease EVENTs (PREVENT) Equations,' Circulation. 2024;149:430–449). The implementation was validated against the open-source preventr reference package and reproduces its published example outputs exactly.
PREVENT reports three 10-year risk percentages. The ASCVD estimate (heart attack and stroke) is most comparable to existing guideline thresholds: low (<5%), borderline (5–7.5%), intermediate (7.5–20%), and high (≥20%). Total CVD adds heart failure to ASCVD and is therefore higher than ASCVD alone. The heart-failure estimate stands on its own and is most influenced by blood pressure, BMI, diabetes, and kidney function.
Because PREVENT was recalibrated on contemporary cohorts, its ASCVD estimates are typically lower than those from the 2013 Pooled Cohort Equations for the same patient. A given percentage represents the expected proportion of people with that risk profile who would experience the event over 10 years — it is a population estimate, not an individual certainty, and is modifiable through treatment and lifestyle change.
Use PREVENT for primary-prevention cardiovascular risk assessment in adults aged 30–79 without established cardiovascular disease. It is especially useful for younger adults (30–39) outside the Pooled Cohort Equations' range, and for patients with obesity, diabetes, or chronic kidney disease where the heart-failure estimate and eGFR/BMI inputs add value. It supports the clinician–patient discussion about statins, blood-pressure treatment, and metabolic risk reduction.
PREVENT estimates risk of a first cardiovascular event and should not be applied to patients with established ASCVD, who are already secondary-prevention candidates. Statin thresholds in current guidelines were derived using the Pooled Cohort Equations, so directly applying those cutoffs to PREVENT's generally lower estimates may under-treat some patients until guidelines are updated.
This tool implements the base model only; the full PREVENT equations can additionally incorporate urine albumin-to-creatinine ratio (UACR), HbA1c, and a social deprivation index for refined estimates. As with any model, PREVENT does not capture every risk-enhancing factor (family history, Lp(a), inflammatory disease), and clinical judgment and shared decision-making remain essential.
Disclaimer: This tool is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about your health.
June 23, 2026 · trust-baseline
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Calculate 10-year ASCVD risk using current 2026 ACC/AHA Pooled Cohort Equations. Statin thresholds: <5% low, 5–7.5% borderline, ≥7.5% intermediate, ≥20% high.
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OpenClinicalCalculate eGFR with the CKD-EPI 2021 race-free formula to estimate kidney function and CKD stage from serum creatinine, age, and sex.
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